Viablife Produce Hydroxytyrosol, Protocatechuic Acid, And Caffeic Acid

Home > News >Antioxidant Eff...

Antioxidant Effects of Caffeic Acid In Vivo and In Vitro


The quest for natural antioxidants has been a focal point in the field of health and nutrition. Caffeic acid, a naturally occurring phenolic compound, has been the subject of numerous studies due to its potential antioxidant properties. In this blog post, Viablife will share with you the antioxidant effects of natural phenolic compound caffeic acid in vivo and in vitro, exploring its mechanism of action and potential health benefits.



Oxidative stress, resulting from an imbalance between the production of reactive oxygen species (ROS) and the body's antioxidant defenses, is implicated in the pathogenesis of various diseases, including cardiovascular diseases, cancer, and neurodegenerative disorders. Antioxidants, capable of neutralizing ROS, are therefore of significant interest in both preventative and therapeutic strategies. Caffeic acid, a bioactive compound found in a variety of plant sources, has garnered attention for its purported antioxidant capabilities.


Chemical Structure and Occurrence:

Caffeic acid is a hydroxycinnamic acid derivative characterized by a 3,4-dihydroxycinnamic acid structure. It is widely distributed in the plant kingdom, particularly in coffee beans, artichokes, and various herbs and spices. Its presence in these dietary sources suggests a potential for dietary intake and subsequent health benefits.

 Caffeic Acid

In Vitro Studies:

1. Scavenging of Free Radicals: Caffeic acid has been shown to effectively scavenge free radicals, including the hydroxyl radical, superoxide anion, and DPPH radicals, demonstrating its direct antioxidant activity.


2. Metal Chelation: The ability of caffeic acid to chelate metal ions, thereby preventing the formation of ROS through Fenton reactions, has been established.


3. Enzymatic Activity: Caffeic acid has also been found to stimulate the activity of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), enhancing the endogenous antioxidant defense system.


4. Lipid Peroxidation Inhibition: Studies have shown that caffeic acid can inhibit lipid peroxidation, a process that leads to cell membrane damage and contributes to oxidative stress.


In Vivo Studies:

1. Oxidative Stress Models: Administration of caffeic acid has been shown to reduce oxidative stress in animal models induced by various agents, such as hydrogen peroxide or chemical carcinogens.


2. Neuroprotection: In studies focusing on neurodegenerative diseases, caffeic acid has demonstrated neuroprotective effects, potentially through its antioxidant and anti-inflammatory properties.


3. Cardiovascular Protection: Research indicates that caffeic acid may protect against cardiovascular diseases by reducing oxidative stress and inflammation in the heart and blood vessels.


4. Cancer Prevention: The chemopreventive potential of caffeic acid has been explored in animal models, with evidence suggesting it can inhibit tumor growth and reduce the incidence of certain cancers.


Mechanisms of Action:

1. Direct Free Radical Scavenging: As observed in vitro, the direct interaction with ROS is a primary mechanism.


2. Modulation of Antioxidant Enzymes: Caffeic acid's ability to modulate the activity of antioxidant enzymes contributes to its in vivo effects.


3. Anti-Inflammatory Effects: By reducing the production of pro-inflammatory cytokines and other mediators, caffeic acid may indirectly reduce oxidative stress.


4. Signal Transduction Pathways: Caffeic acid may modulate various cellular signaling pathways involved in the regulation of oxidative stress and cell survival.


Health Benefits:

The antioxidant properties of caffeic acid have been linked to a range of health benefits, including:

1. Reduced Risk of Chronic Diseases: By neutralizing ROS and reducing inflammation, caffeic acid may lower the risk of chronic diseases associated with oxidative stress.


2. Enhanced Immune Function: Its effects on immune cell function and inflammatory mediators suggest a role in modulating immune responses.


3. Improved Cognitive Function: The neuroprotective effects of caffeic acid may contribute to maintaining cognitive health and preventing neurodegenerative disorders.


4. Aesthetic Benefits: As an antioxidant, caffeic acid may also have applications in skincare, protecting against environmental damage and promoting skin health.

 Caffeic Acid For Sale

Why Choose Viablife's Caffeic Acid?

Viablife distinguishes itself with its high-purity (>99%) caffeic acid, crafted through cutting-edge biosynthesis and fermentation technology. While typical offerings range between 70%-90% purity, Viablife ensures superior quality. Connect with us to explore our biomedical offerings and elevate your wellness journey with Viablife's premium caffeic acid.


Related Products:

1. Nicotinamide

2. Hydroxytyrosol

3. Ceramide NP

4. Arbutin

Relevant information
Leave a Message
Privacy Agreement

Platform information submission - privacy agreement

● Privacy Policy

We are committed to protecting the privacy, personal data and personal data (collectively referred to as "personal data") provided by you when using this website. Make us comply with the highest standards in terms of collection, use, storage and transmission of personal data (laws and regulations related to privacy of personal data) and consumer protection. To ensure that you have full confidence in the handling of personal data on this website, you must carefully read and understand the provisions of the privacy policy. This website (hereinafter referred to as "us") respects and protects the privacy of users. In particular, once you use this website, you will be deemed to accept, agree, promise and confirm this privacy agreement; You disclose your personal data to us voluntarily with the required consent; You will abide by any modification of this privacy policy; You agree that our relevant business personnel will contact you regarding the products and services you may be interested in (unless you have indicated that you do not want to receive such messages). With your consent, we will collect, manage and monitor the types of personal data collected

1. Scope of application

It is our unremitting pursuit to provide users with better, better and more personalized services. We also hope that the services we provide will be more convenient for your needs. This privacy policy applies to all information collection services provided by this website. You can visit this website and use the services provided by this website using this privacy policy

2. What information do we collect

In order to provide you with our various services, you need to provide personal data information, including personal data and anonymous data, including but not limited to: personal data (your name, gender, age, date of birth, telephone number, fax number, address or mailing address, e-mail address, etc.)

3. How to use the collected information

The purposes and purposes of collecting personal data and anonymous data are as follows: to provide you with our services through this website; When you use our website, you can identify and confirm your identity; Let you get the service for you when you use this website; The relevant business personnel of this website can contact you when necessary; Make it more convenient for you to use this website; The personal data and anonymous data provided by you to us will only be retained until the collection purpose has been achieved, unless they are retained due to applicable laws and regulations. The ownership of personal data and disclosure of all data collected on our website are owned by us and will not be leased or sold to any unrelated third party

4. How do we protect information

For the protection of personal data, we implement appropriate physical, electronic and management measures to protect and guarantee the safety of your personal data. We try our best to ensure that any personal data collected through this website is free from any nuisance of a third party unrelated to us. The security measures we take are not limited to: physical measures: the records with your personal data will be stored in a locked place Electronic measures: the computer data with your personal data will be stored in the computer system and storage media subject to strict login restrictions Management measures: only employees authorized by us can access your personal data, These employees need to comply with our internal rules on the confidentiality of personal data. If you are aware of any security loopholes on this website, please contact us in time so that we can take appropriate actions as soon as possible; Despite the implementation of the above security measures, we cannot guarantee the absolute security of data transmission on the Internet, so we cannot absolutely guarantee that the personal data and anonymous data you provide to us through this website are safe at all times. We will not be responsible for any unauthorized access to your personal data, and we will not be responsible for any losses and damages incurred or caused in this regard.

5. Juvenile Protection Law

The minor has provided personal data to this website without the approval or consent of any parent or guardian. Please contact the public telephone number and customer service telephone number on this website in time to ensure that the data are removed

6. Revision and effectiveness of privacy policy

With the expansion of the service scope of this website, we may revise the Legal Statement and Privacy Policy from time to time, which forms a part of this Legal Statement and Privacy Policy. In order to prevent you from being informed of such revisions, please read this Legal Statement and Privacy Policy frequently. In any way, if you continue to use our services, you agree to be bound by the revised Legal Statement and Privacy Policy

Address:3rd Floor, Building No.5,Liangzhu University Science Park,Yuhang District,Hangzhou,Zhejianga



Agree and continue