Viablife New Generation Nicotinamide: Unlocking the Potential of Nicotinamide Through Synthetic Biology: Expanding Application Horizons

In today' s efficacy-driven beauty landscape, nicotinamide (also known as niacinamide) remains a cornerstone ingredient in cosmetic formulations, celebrated for its clinically proven benefits in brightening, anti-aging, barrier repair, and anti-inflammation. Yet despite its widespread use and well-documented mechanisms of action, the production of nicotinamide has seen little technological advancement in recent years. Its relatively low raw material cost and mature synthesis process have discouraged further innovation, leaving a gap between the growing demand for high-performance skincare and the limited evolution of active ingredient supply. However, the true appeal of nicotinamide lies in its untapped potential—both in efficacy and in expanded application scenarios.

Viablife, a leader in synthetic biology in China, has chosen a bold and visionary path forward. Guided by the belief that "classics endure, but innovation leads," the company has redefined nicotinamide through cutting-edge biotechnological advancements, unveiling a new generation of this iconic ingredient. This New Generation Nicotinamide excels in four key areas: higher purity, greater gentleness, enhanced safety, and superior quality—transforming the role of nicotinamide in contemporary cosmetics.

1. Higher Purity: Maximizing Purity with Bio-Synthesis Technology

Traditional chemical synthesis of nicotinamide is often constrained by low conversion efficiency, high energy consumption, and the presence of residual impurities. These impurities can introduce safety risks or cause instability in formulations.

Viablife addresses these limitations by leveraging synthetic biology to construct a multi-enzyme cascade cell factory. This bio-conversion method dramatically improves reaction efficiency while minimizing energy use. As a result, Viablife's New Generation Nicotinamide reaches ultra-high purity levels (up to 99.9%), with negligible levels of heavy metals and microbiological contaminants. This clean, bio-derived production process not only meets but exceeds the strict safety standards set by the *Cosmetic Safety Technical Specification* in China.

For cosmetic brands committed to clean beauty and high-performance actives, Viablife' s New Generation Nicotinamide ensures formulation stability, skin compatibility, and long-term consumer safety.

2. Greater Gentleness: Reducing Irritation for Sensitive Skin Compatibility

One of the longstanding challenges with nicotinamide use is its impurity—particularly the presence of nicotinic acid (niacin). Even trace amounts of this compound can activate the arachidonic acid pathway in skin Langerhans cells, triggering the release of inflammatory mediators such as prostaglandin E2 (PGE2). This response may cause redness, tingling, and itching, especially in individuals with sensitive skin.

According to a 2024 clinical patch test conducted by an independent third party involving 167 participants, formulations containing 100 ppm of nicotinic acid caused adverse skin reactions in 41.92% of subjects within 24 hours. When the nicotinic acid content was reduced to 10 ppm, the adverse reaction rate dropped significantly to 2.4%.

Recognizing the critical importance of this threshold, Viablife developed a proprietary purification technology (Patent No. CN202011620674.3) that consistently maintains nicotinic acid levels below 10 ppm. This breakthrough significantly reduces the risk of irritation, allowing for the formulation of products suitable even for highly sensitive skin and thereby expanding the potential user base for nicotinamide-based products.

3. Enhanced Safety: Complete and Verified Safety Evaluation

Product safety is non-negotiable—especially in an era of increasingly stringent regulatory oversight and heightened consumer awareness. Viablife' s New Generation Nicotinamide has successfully passed a comprehensive safety evaluation, covering hazard identification, dose-response assessment, exposure analysis, and risk characterization.

Third-party toxicity and irritation assessments have further confirmed Viablife' s New Generation Nicotinamide robust safety profile. At concentrations up to 20%, it is considered safe for use in most typical cosmetic formulations—including creams, serums, cleansers, and essences. For products like body lotions, full-body sunscreens, sheet masks, and toners, scientific data supports safe usage at concentrations up to 13.57%

Human trials also substantiate these claims:

* In a study with 30 subjects using 5%, 7%, 8%, and 10% concentrations, no sensitization or adverse skin reactions were observed.

In another trial involving 62 participants using 10% and 15% concentrations over four weeks, no irritation was observed. Moreover, skin lactic acid stinging scores showed significant improvement, indicating enhanced skin tolerance. 

This positions Viablife' s New Generation Nicotinamide as one of the few high-concentration active ingredients that deliver both proven efficacy and exceptional skin safety—even for sensitive users.

4. Superior Quality: Recognized Innovation and Broad Market Adoption

Beyond its technical superiority, Viablife' s New Generation Nicotinamide has also earned broad industry recognition and robust intellectual property protection. To date, it holds seven patent applications and has received prestigious accolades, including:

* CIC Innovative Cosmetic Ingredients Award

* CIC Innovative Processing Technology Award

* 2025 Ringier Technology Innovation Award (Personal Care Sector)

These achievements are further reflected in its commercial success and brand trust. Viablife's New Generation Nicotinamide is now incorporated by over 400 global and domestic beauty brands, including market leaders such as Proya, OSM, Betaine, P&G, and Amorepacific. Among China' s top 100 cosmetic brands, Viablife' s New Generation Nicotinamide holds an impressive 40% market share—underscoring its exceptional quality and innovation-driven value proposition.

By continuously enriching the narrative and functionality of this classic ingredient, Viablife not only reaffirms nicotinamide' s legacy but also redefines its future.

Conclusion: Innovation as the Pathway to Excellence

In a cosmetics industry that is evolving toward higher quality and greater transparency, Viablife stands at the frontier of ingredient innovation. The company's persistent investment in R&D and synthetic biology allows it to unlock new potential from trusted ingredients like nicotinamide-- elevating them beyond commodities into strategic assets for skincare efficacy and brand differentiation.

Viablife's mission, "To Create a Better Future through Innovation", exemplifies how continuous innovation can breathe new life into established ingredients. Its New Generation Nicotinamide is more than an upgraded material - it is a symbol of how biotechnology can empower the future of cosmetics: cleaner, gentler, safer, and superior in every aspect.

As the skincare industry advances into a new era of precision and personalization, Viablife' s pioneering spirit ensures it will continue to lead—not only through its products but also through its visionary approach.